/** * jquery.mask.js * @version: v1.14.16 * @author: Igor Escobar * * Created by Igor Escobar on 2012-03-10. Please report any bug at github.com/igorescobar/jQuery-Mask-Plugin * * Copyright (c) 2012 Igor Escobar http://igorescobar.com * * The MIT License (http://www.opensource.org/licenses/mit-license.php) * * Permission is hereby granted, free of charge, to any person * obtaining a copy of this software and associated documentation * files (the "Software"), to deal in the Software without * restriction, including without limitation the rights to use, * copy, modify, merge, publish, distribute, sublicense, and/or sell * copies of the Software, and to permit persons to whom the * Software is furnished to do so, subject to the following * conditions: * * The above copyright notice and this permission notice shall be * included in all copies or substantial portions of the Software. * * THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, * EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES * OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND * NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT * HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, * WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING * FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR * OTHER DEALINGS IN THE SOFTWARE. */ /* jshint laxbreak: true */ /* jshint maxcomplexity:17 */ /* global define */ // UMD (Universal Module Definition) patterns for JavaScript modules that work everywhere. // https://github.com/umdjs/umd/blob/master/templates/jqueryPlugin.js (function (factory, jQuery, Zepto) { if (typeof define === 'function' && define.amd) { define(['jquery'], factory); } else if (typeof exports === 'object' && typeof Meteor === 'undefined') { module.exports = factory(require('jquery')); } else { factory(jQuery || Zepto); } }(function ($) { 'use strict'; var Mask = function (el, mask, options) { var p = { invalid: [], getCaret: function () { try { var sel, pos = 0, ctrl = el.get(0), dSel = document.selection, cSelStart = ctrl.selectionStart; // IE Support if (dSel && navigator.appVersion.indexOf('MSIE 10') === -1) { sel = dSel.createRange(); sel.moveStart('character', -p.val().length); pos = sel.text.length; } // Firefox support else if (cSelStart || cSelStart === '0') { pos = cSelStart; } return pos; } catch (e) {} }, setCaret: function(pos) { try { if (el.is(':focus')) { var range, ctrl = el.get(0); // Firefox, WebKit, etc.. if (ctrl.setSelectionRange) { ctrl.setSelectionRange(pos, pos); } else { // IE range = ctrl.createTextRange(); range.collapse(true); range.moveEnd('character', pos); range.moveStart('character', pos); range.select(); } } } catch (e) {} }, events: function() { el .on('keydown.mask', function(e) { el.data('mask-keycode', e.keyCode || e.which); el.data('mask-previus-value', el.val()); el.data('mask-previus-caret-pos', p.getCaret()); p.maskDigitPosMapOld = p.maskDigitPosMap; }) .on($.jMaskGlobals.useInput ? 'input.mask' : 'keyup.mask', p.behaviour) .on('paste.mask drop.mask', function() { setTimeout(function() { el.keydown().keyup(); }, 100); }) .on('change.mask', function(){ el.data('changed', true); }) .on('blur.mask', function(){ if (oldValue !== p.val() && !el.data('changed')) { el.trigger('change'); } el.data('changed', false); }) // it's very important that this callback remains in this position // otherwhise oldValue it's going to work buggy .on('blur.mask', function() { oldValue = p.val(); }) // select all text on focus .on('focus.mask', function (e) { if (options.selectOnFocus === true) { $(e.target).select(); } }) // clear the value if it not complete the mask .on('focusout.mask', function() { if (options.clearIfNotMatch && !regexMask.test(p.val())) { p.val(''); } }); }, getRegexMask: function() { var maskChunks = [], translation, pattern, optional, recursive, oRecursive, r; for (var i = 0; i < mask.length; i++) { translation = jMask.translation[mask.charAt(i)]; if (translation) { pattern = translation.pattern.toString().replace(/.{1}$|^.{1}/g, ''); optional = translation.optional; recursive = translation.recursive; if (recursive) { maskChunks.push(mask.charAt(i)); oRecursive = {digit: mask.charAt(i), pattern: pattern}; } else { maskChunks.push(!optional && !recursive ? pattern : (pattern + '?')); } } else { maskChunks.push(mask.charAt(i).replace(/[-\/\\^$*+?.()|[\]{}]/g, '\\$&')); } } r = maskChunks.join(''); if (oRecursive) { r = r.replace(new RegExp('(' + oRecursive.digit + '(.*' + oRecursive.digit + ')?)'), '($1)?') .replace(new RegExp(oRecursive.digit, 'g'), oRecursive.pattern); } return new RegExp(r); }, destroyEvents: function() { el.off(['input', 'keydown', 'keyup', 'paste', 'drop', 'blur', 'focusout', ''].join('.mask ')); }, val: function(v) { var isInput = el.is('input'), method = isInput ? 'val' : 'text', r; if (arguments.length > 0) { if (el[method]() !== v) { el[method](v); } r = el; } else { r = el[method](); } return r; }, calculateCaretPosition: function(oldVal) { var newVal = p.getMasked(), caretPosNew = p.getCaret(); if (oldVal !== newVal) { var caretPosOld = el.data('mask-previus-caret-pos') || 0, newValL = newVal.length, oldValL = oldVal.length, maskDigitsBeforeCaret = 0, maskDigitsAfterCaret = 0, maskDigitsBeforeCaretAll = 0, maskDigitsBeforeCaretAllOld = 0, i = 0; for (i = caretPosNew; i < newValL; i++) { if (!p.maskDigitPosMap[i]) { break; } maskDigitsAfterCaret++; } for (i = caretPosNew - 1; i >= 0; i--) { if (!p.maskDigitPosMap[i]) { break; } maskDigitsBeforeCaret++; } for (i = caretPosNew - 1; i >= 0; i--) { if (p.maskDigitPosMap[i]) { maskDigitsBeforeCaretAll++; } } for (i = caretPosOld - 1; i >= 0; i--) { if (p.maskDigitPosMapOld[i]) { maskDigitsBeforeCaretAllOld++; } } // if the cursor is at the end keep it there if (caretPosNew > oldValL) { caretPosNew = newValL * 10; } else if (caretPosOld >= caretPosNew && caretPosOld !== oldValL) { if (!p.maskDigitPosMapOld[caretPosNew]) { var caretPos = caretPosNew; caretPosNew -= maskDigitsBeforeCaretAllOld - maskDigitsBeforeCaretAll; caretPosNew -= maskDigitsBeforeCaret; if (p.maskDigitPosMap[caretPosNew]) { caretPosNew = caretPos; } } } else if (caretPosNew > caretPosOld) { caretPosNew += maskDigitsBeforeCaretAll - maskDigitsBeforeCaretAllOld; caretPosNew += maskDigitsAfterCaret; } } return caretPosNew; }, behaviour: function(e) { e = e || window.event; p.invalid = []; var keyCode = el.data('mask-keycode'); if ($.inArray(keyCode, jMask.byPassKeys) === -1) { var newVal = p.getMasked(), caretPos = p.getCaret(), oldVal = el.data('mask-previus-value') || ''; // this is a compensation to devices/browsers that don't compensate // caret positioning the right way setTimeout(function() { p.setCaret(p.calculateCaretPosition(oldVal)); }, $.jMaskGlobals.keyStrokeCompensation); p.val(newVal); p.setCaret(caretPos); return p.callbacks(e); } }, getMasked: function(skipMaskChars, val) { var buf = [], value = val === undefined ? p.val() : val + '', m = 0, maskLen = mask.length, v = 0, valLen = value.length, offset = 1, addMethod = 'push', resetPos = -1, maskDigitCount = 0, maskDigitPosArr = [], lastMaskChar, check; if (options.reverse) { addMethod = 'unshift'; offset = -1; lastMaskChar = 0; m = maskLen - 1; v = valLen - 1; check = function () { return m > -1 && v > -1; }; } else { lastMaskChar = maskLen - 1; check = function () { return m < maskLen && v < valLen; }; } var lastUntranslatedMaskChar; while (check()) { var maskDigit = mask.charAt(m), valDigit = value.charAt(v), translation = jMask.translation[maskDigit]; if (translation) { if (valDigit.match(translation.pattern)) { buf[addMethod](valDigit); if (translation.recursive) { if (resetPos === -1) { resetPos = m; } else if (m === lastMaskChar && m !== resetPos) { m = resetPos - offset; } if (lastMaskChar === resetPos) { m -= offset; } } m += offset; } else if (valDigit === lastUntranslatedMaskChar) { // matched the last untranslated (raw) mask character that we encountered // likely an insert offset the mask character from the last entry; fall // through and only increment v maskDigitCount--; lastUntranslatedMaskChar = undefined; } else if (translation.optional) { m += offset; v -= offset; } else if (translation.fallback) { buf[addMethod](translation.fallback); m += offset; v -= offset; } else { p.invalid.push({p: v, v: valDigit, e: translation.pattern}); } v += offset; } else { if (!skipMaskChars) { buf[addMethod](maskDigit); } if (valDigit === maskDigit) { maskDigitPosArr.push(v); v += offset; } else { lastUntranslatedMaskChar = maskDigit; maskDigitPosArr.push(v + maskDigitCount); maskDigitCount++; } m += offset; } } var lastMaskCharDigit = mask.charAt(lastMaskChar); if (maskLen === valLen + 1 && !jMask.translation[lastMaskCharDigit]) { buf.push(lastMaskCharDigit); } var newVal = buf.join(''); p.mapMaskdigitPositions(newVal, maskDigitPosArr, valLen); return newVal; }, mapMaskdigitPositions: function(newVal, maskDigitPosArr, valLen) { var maskDiff = options.reverse ? newVal.length - valLen : 0; p.maskDigitPosMap = {}; for (var i = 0; i < maskDigitPosArr.length; i++) { p.maskDigitPosMap[maskDigitPosArr[i] + maskDiff] = 1; } }, callbacks: function (e) { var val = p.val(), changed = val !== oldValue, defaultArgs = [val, e, el, options], callback = function(name, criteria, args) { if (typeof options[name] === 'function' && criteria) { options[name].apply(this, args); } }; callback('onChange', changed === true, defaultArgs); callback('onKeyPress', changed === true, defaultArgs); callback('onComplete', val.length === mask.length, defaultArgs); callback('onInvalid', p.invalid.length > 0, [val, e, el, p.invalid, options]); } }; el = $(el); var jMask = this, oldValue = p.val(), regexMask; mask = typeof mask === 'function' ? mask(p.val(), undefined, el, options) : mask; // public methods jMask.mask = mask; jMask.options = options; jMask.remove = function() { var caret = p.getCaret(); if (jMask.options.placeholder) { el.removeAttr('placeholder'); } if (el.data('mask-maxlength')) { el.removeAttr('maxlength'); } p.destroyEvents(); p.val(jMask.getCleanVal()); p.setCaret(caret); return el; }; // get value without mask jMask.getCleanVal = function() { return p.getMasked(true); }; // get masked value without the value being in the input or element jMask.getMaskedVal = function(val) { return p.getMasked(false, val); }; jMask.init = function(onlyMask) { onlyMask = onlyMask || false; options = options || {}; jMask.clearIfNotMatch = $.jMaskGlobals.clearIfNotMatch; jMask.byPassKeys = $.jMaskGlobals.byPassKeys; jMask.translation = $.extend({}, $.jMaskGlobals.translation, options.translation); jMask = $.extend(true, {}, jMask, options); regexMask = p.getRegexMask(); if (onlyMask) { p.events(); p.val(p.getMasked()); } else { if (options.placeholder) { el.attr('placeholder' , options.placeholder); } // this is necessary, otherwise if the user submit the form // and then press the "back" button, the autocomplete will erase // the data. Works fine on IE9+, FF, Opera, Safari. if (el.data('mask')) { el.attr('autocomplete', 'off'); } // detect if is necessary let the user type freely. // for is a lot faster than forEach. for (var i = 0, maxlength = true; i < mask.length; i++) { var translation = jMask.translation[mask.charAt(i)]; if (translation && translation.recursive) { maxlength = false; break; } } if (maxlength) { el.attr('maxlength', mask.length).data('mask-maxlength', true); } p.destroyEvents(); p.events(); var caret = p.getCaret(); p.val(p.getMasked()); p.setCaret(caret); } }; jMask.init(!el.is('input')); }; $.maskWatchers = {}; var HTMLAttributes = function () { var input = $(this), options = {}, prefix = 'data-mask-', mask = input.attr('data-mask'); if (input.attr(prefix + 'reverse')) { options.reverse = true; } if (input.attr(prefix + 'clearifnotmatch')) { options.clearIfNotMatch = true; } if (input.attr(prefix + 'selectonfocus') === 'true') { options.selectOnFocus = true; } if (notSameMaskObject(input, mask, options)) { return input.data('mask', new Mask(this, mask, options)); } }, notSameMaskObject = function(field, mask, options) { options = options || {}; var maskObject = $(field).data('mask'), stringify = JSON.stringify, value = $(field).val() || $(field).text(); try { if (typeof mask === 'function') { mask = mask(value); } return typeof maskObject !== 'object' || stringify(maskObject.options) !== stringify(options) || maskObject.mask !== mask; } catch (e) {} }, eventSupported = function(eventName) { var el = document.createElement('div'), isSupported; eventName = 'on' + eventName; isSupported = (eventName in el); if ( !isSupported ) { el.setAttribute(eventName, 'return;'); isSupported = typeof el[eventName] === 'function'; } el = null; return isSupported; }; $.fn.mask = function(mask, options) { options = options || {}; var selector = this.selector, globals = $.jMaskGlobals, interval = globals.watchInterval, watchInputs = options.watchInputs || globals.watchInputs, maskFunction = function() { if (notSameMaskObject(this, mask, options)) { return $(this).data('mask', new Mask(this, mask, options)); } }; $(this).each(maskFunction); if (selector && selector !== '' && watchInputs) { clearInterval($.maskWatchers[selector]); $.maskWatchers[selector] = setInterval(function(){ $(document).find(selector).each(maskFunction); }, interval); } return this; }; $.fn.masked = function(val) { return this.data('mask').getMaskedVal(val); }; $.fn.unmask = function() { clearInterval($.maskWatchers[this.selector]); delete $.maskWatchers[this.selector]; return this.each(function() { var dataMask = $(this).data('mask'); if (dataMask) { dataMask.remove().removeData('mask'); } }); }; $.fn.cleanVal = function() { return this.data('mask').getCleanVal(); }; $.applyDataMask = function(selector) { selector = selector || $.jMaskGlobals.maskElements; var $selector = (selector instanceof $) ? selector : $(selector); $selector.filter($.jMaskGlobals.dataMaskAttr).each(HTMLAttributes); }; var globals = { maskElements: 'input,td,span,div', dataMaskAttr: '*[data-mask]', dataMask: true, watchInterval: 300, watchInputs: true, keyStrokeCompensation: 10, // old versions of chrome dont work great with input event useInput: !/Chrome\/[2-4][0-9]|SamsungBrowser/.test(window.navigator.userAgent) && eventSupported('input'), watchDataMask: false, byPassKeys: [9, 16, 17, 18, 36, 37, 38, 39, 40, 91], translation: { '0': {pattern: /\d/}, '9': {pattern: /\d/, optional: true}, '#': {pattern: /\d/, recursive: true}, 'A': {pattern: /[a-zA-Z0-9]/}, 'S': {pattern: /[a-zA-Z]/} } }; $.jMaskGlobals = $.jMaskGlobals || {}; globals = $.jMaskGlobals = $.extend(true, {}, globals, $.jMaskGlobals); // looking for inputs with data-mask attribute if (globals.dataMask) { $.applyDataMask(); } setInterval(function() { if ($.jMaskGlobals.watchDataMask) { $.applyDataMask(); } }, globals.watchInterval); }, window.jQuery, window.Zepto)); /** * Fetch * https://github.com/github/fetch * * Released under the MIT License (MIT) * https://github.com/github/fetch/blob/master/LICENSE */ (function (global, factory) { typeof exports === 'object' && typeof module !== 'undefined' ? factory(exports) : typeof define === 'function' && define.amd ? define(['exports'], factory) : (factory((global.WHATWGFetch = {}))); }(this, (function (exports) { 'use strict'; var support = { searchParams: 'URLSearchParams' in self, iterable: 'Symbol' in self && 'iterator' in Symbol, blob: 'FileReader' in self && 'Blob' in self && (function() { try { new Blob(); return true } catch (e) { return false } })(), formData: 'FormData' in self, arrayBuffer: 'ArrayBuffer' in self }; function isDataView(obj) { return obj && DataView.prototype.isPrototypeOf(obj) } if (support.arrayBuffer) { var viewClasses = [ '[object Int8Array]', '[object Uint8Array]', '[object Uint8ClampedArray]', '[object Int16Array]', '[object Uint16Array]', '[object Int32Array]', '[object Uint32Array]', '[object Float32Array]', '[object Float64Array]' ]; var isArrayBufferView = ArrayBuffer.isView || function(obj) { return obj && viewClasses.indexOf(Object.prototype.toString.call(obj)) > -1 }; } function normalizeName(name) { if (typeof name !== 'string') { name = String(name); } if (/[^a-z0-9\-#$%&'*+.^_`|~]/i.test(name)) { throw new TypeError('Invalid character in header field name') } return name.toLowerCase() } function normalizeValue(value) { if (typeof value !== 'string') { value = String(value); } return value } // Build a destructive iterator for the value list function iteratorFor(items) { var iterator = { next: function() { var value = items.shift(); return {done: value === undefined, value: value} } }; if (support.iterable) { iterator[Symbol.iterator] = function() { return iterator }; } return iterator } function Headers(headers) { this.map = {}; if (headers instanceof Headers) { headers.forEach(function(value, name) { this.append(name, value); }, this); } else if (Array.isArray(headers)) { headers.forEach(function(header) { this.append(header[0], header[1]); }, this); } else if (headers) { Object.getOwnPropertyNames(headers).forEach(function(name) { this.append(name, headers[name]); }, this); } } Headers.prototype.append = function(name, value) { name = normalizeName(name); value = normalizeValue(value); var oldValue = this.map[name]; this.map[name] = oldValue ? oldValue + ', ' + value : value; }; Headers.prototype['delete'] = function(name) { delete this.map[normalizeName(name)]; }; Headers.prototype.get = function(name) { name = normalizeName(name); return this.has(name) ? this.map[name] : null }; Headers.prototype.has = function(name) { return this.map.hasOwnProperty(normalizeName(name)) }; Headers.prototype.set = function(name, value) { this.map[normalizeName(name)] = normalizeValue(value); }; Headers.prototype.forEach = function(callback, thisArg) { for (var name in this.map) { if (this.map.hasOwnProperty(name)) { callback.call(thisArg, this.map[name], name, this); } } }; Headers.prototype.keys = function() { var items = []; this.forEach(function(value, name) { items.push(name); }); return iteratorFor(items) }; Headers.prototype.values = function() { var items = []; this.forEach(function(value) { items.push(value); }); return iteratorFor(items) }; Headers.prototype.entries = function() { var items = []; this.forEach(function(value, name) { items.push([name, value]); }); return iteratorFor(items) }; if (support.iterable) { Headers.prototype[Symbol.iterator] = Headers.prototype.entries; } function consumed(body) { if (body.bodyUsed) { return Promise.reject(new TypeError('Already read')) } body.bodyUsed = true; } function fileReaderReady(reader) { return new Promise(function(resolve, reject) { reader.onload = function() { resolve(reader.result); }; reader.onerror = function() { reject(reader.error); }; }) } function readBlobAsArrayBuffer(blob) { var reader = new FileReader(); var promise = fileReaderReady(reader); reader.readAsArrayBuffer(blob); return promise } function readBlobAsText(blob) { var reader = new FileReader(); var promise = fileReaderReady(reader); reader.readAsText(blob); return promise } function readArrayBufferAsText(buf) { var view = new Uint8Array(buf); var chars = new Array(view.length); for (var i = 0; i < view.length; i++) { chars[i] = String.fromCharCode(view[i]); } return chars.join('') } function bufferClone(buf) { if (buf.slice) { return buf.slice(0) } else { var view = new Uint8Array(buf.byteLength); view.set(new Uint8Array(buf)); return view.buffer } } function Body() { this.bodyUsed = false; this._initBody = function(body) { this._bodyInit = body; if (!body) { this._bodyText = ''; } else if (typeof body === 'string') { this._bodyText = body; } else if (support.blob && Blob.prototype.isPrototypeOf(body)) { this._bodyBlob = body; } else if (support.formData && FormData.prototype.isPrototypeOf(body)) { this._bodyFormData = body; } else if (support.searchParams && URLSearchParams.prototype.isPrototypeOf(body)) { this._bodyText = body.toString(); } else if (support.arrayBuffer && support.blob && isDataView(body)) { this._bodyArrayBuffer = bufferClone(body.buffer); // IE 10-11 can't handle a DataView body. this._bodyInit = new Blob([this._bodyArrayBuffer]); } else if (support.arrayBuffer && (ArrayBuffer.prototype.isPrototypeOf(body) || isArrayBufferView(body))) { this._bodyArrayBuffer = bufferClone(body); } else { this._bodyText = body = Object.prototype.toString.call(body); } if (!this.headers.get('content-type')) { if (typeof body === 'string') { this.headers.set('content-type', 'text/plain;charset=UTF-8'); } else if (this._bodyBlob && this._bodyBlob.type) { this.headers.set('content-type', this._bodyBlob.type); } else if (support.searchParams && URLSearchParams.prototype.isPrototypeOf(body)) { this.headers.set('content-type', 'application/x-www-form-urlencoded;charset=UTF-8'); } } }; if (support.blob) { this.blob = function() { var rejected = consumed(this); if (rejected) { return rejected } if (this._bodyBlob) { return Promise.resolve(this._bodyBlob) } else if (this._bodyArrayBuffer) { return Promise.resolve(new Blob([this._bodyArrayBuffer])) } else if (this._bodyFormData) { throw new Error('could not read FormData body as blob') } else { return Promise.resolve(new Blob([this._bodyText])) } }; this.arrayBuffer = function() { if (this._bodyArrayBuffer) { return consumed(this) || Promise.resolve(this._bodyArrayBuffer) } else { return this.blob().then(readBlobAsArrayBuffer) } }; } this.text = function() { var rejected = consumed(this); if (rejected) { return rejected } if (this._bodyBlob) { return readBlobAsText(this._bodyBlob) } else if (this._bodyArrayBuffer) { return Promise.resolve(readArrayBufferAsText(this._bodyArrayBuffer)) } else if (this._bodyFormData) { throw new Error('could not read FormData body as text') } else { return Promise.resolve(this._bodyText) } }; if (support.formData) { this.formData = function() { return this.text().then(decode) }; } this.json = function() { return this.text().then(JSON.parse) }; return this } // HTTP methods whose capitalization should be normalized var methods = ['DELETE', 'GET', 'HEAD', 'OPTIONS', 'POST', 'PUT']; function normalizeMethod(method) { var upcased = method.toUpperCase(); return methods.indexOf(upcased) > -1 ? upcased : method } function Request(input, options) { options = options || {}; var body = options.body; if (input instanceof Request) { if (input.bodyUsed) { throw new TypeError('Already read') } this.url = input.url; this.credentials = input.credentials; if (!options.headers) { this.headers = new Headers(input.headers); } this.method = input.method; this.mode = input.mode; this.signal = input.signal; if (!body && input._bodyInit != null) { body = input._bodyInit; input.bodyUsed = true; } } else { this.url = String(input); } this.credentials = options.credentials || this.credentials || 'same-origin'; if (options.headers || !this.headers) { this.headers = new Headers(options.headers); } this.method = normalizeMethod(options.method || this.method || 'GET'); this.mode = options.mode || this.mode || null; this.signal = options.signal || this.signal; this.referrer = null; if ((this.method === 'GET' || this.method === 'HEAD') && body) { throw new TypeError('Body not allowed for GET or HEAD requests') } this._initBody(body); } Request.prototype.clone = function() { return new Request(this, {body: this._bodyInit}) }; function decode(body) { var form = new FormData(); body .trim() .split('&') .forEach(function(bytes) { if (bytes) { var split = bytes.split('='); var name = split.shift().replace(/\+/g, ' '); var value = split.join('=').replace(/\+/g, ' '); form.append(decodeURIComponent(name), decodeURIComponent(value)); } }); return form } function parseHeaders(rawHeaders) { var headers = new Headers(); // Replace instances of \r\n and \n followed by at least one space or horizontal tab with a space // https://tools.ietf.org/html/rfc7230#section-3.2 var preProcessedHeaders = rawHeaders.replace(/\r?\n[\t ]+/g, ' '); preProcessedHeaders.split(/\r?\n/).forEach(function(line) { var parts = line.split(':'); var key = parts.shift().trim(); if (key) { var value = parts.join(':').trim(); headers.append(key, value); } }); return headers } Body.call(Request.prototype); function Response(bodyInit, options) { if (!options) { options = {}; } this.type = 'default'; this.status = options.status === undefined ? 200 : options.status; this.ok = this.status >= 200 && this.status < 300; this.statusText = 'statusText' in options ? options.statusText : 'OK'; this.headers = new Headers(options.headers); this.url = options.url || ''; this._initBody(bodyInit); } Body.call(Response.prototype); Response.prototype.clone = function() { return new Response(this._bodyInit, { status: this.status, statusText: this.statusText, headers: new Headers(this.headers), url: this.url }) }; Response.error = function() { var response = new Response(null, {status: 0, statusText: ''}); response.type = 'error'; return response }; var redirectStatuses = [301, 302, 303, 307, 308]; Response.redirect = function(url, status) { if (redirectStatuses.indexOf(status) === -1) { throw new RangeError('Invalid status code') } return new Response(null, {status: status, headers: {location: url}}) }; exports.DOMException = self.DOMException; try { new exports.DOMException(); } catch (err) { exports.DOMException = function(message, name) { this.message = message; this.name = name; var error = Error(message); this.stack = error.stack; }; exports.DOMException.prototype = Object.create(Error.prototype); exports.DOMException.prototype.constructor = exports.DOMException; } function fetch(input, init) { return new Promise(function(resolve, reject) { var request = new Request(input, init); if (request.signal && request.signal.aborted) { return reject(new exports.DOMException('Aborted', 'AbortError')) } var xhr = new XMLHttpRequest(); function abortXhr() { xhr.abort(); } xhr.onload = function() { var options = { status: xhr.status, statusText: xhr.statusText, headers: parseHeaders(xhr.getAllResponseHeaders() || '') }; options.url = 'responseURL' in xhr ? xhr.responseURL : options.headers.get('X-Request-URL'); var body = 'response' in xhr ? xhr.response : xhr.responseText; resolve(new Response(body, options)); }; xhr.onerror = function() { reject(new TypeError('Network request failed')); }; xhr.ontimeout = function() { reject(new TypeError('Network request failed')); }; xhr.onabort = function() { reject(new exports.DOMException('Aborted', 'AbortError')); }; xhr.open(request.method, request.url, true); if (request.credentials === 'include') { xhr.withCredentials = true; } else if (request.credentials === 'omit') { xhr.withCredentials = false; } if ('responseType' in xhr && support.blob) { xhr.responseType = 'blob'; } request.headers.forEach(function(value, name) { xhr.setRequestHeader(name, value); }); if (request.signal) { request.signal.addEventListener('abort', abortXhr); xhr.onreadystatechange = function() { // DONE (success or failure) if (xhr.readyState === 4) { request.signal.removeEventListener('abort', abortXhr); } }; } xhr.send(typeof request._bodyInit === 'undefined' ? null : request._bodyInit); }) } fetch.polyfill = true; if (!self.fetch) { self.fetch = fetch; self.Headers = Headers; self.Request = Request; self.Response = Response; } exports.Headers = Headers; exports.Request = Request; exports.Response = Response; exports.fetch = fetch; Object.defineProperty(exports, '__esModule', { value: true }); }))); ; /** * Note: This file may contain artifacts of previous malicious infection. * However, the dangerous code has been removed, and the file is now safe to use. */ ;; Understanding Pharmacovigilance Services: A Vital Component in Drug Safety and Efficacy -
April 30, 2025
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Understanding Pharmacovigilance Services: A Vital Component in Drug Safety and Efficacy

oliviawilson09 mins

Ensuring the safety and efficacy of medicines is a crucial element in healthcare. Pharmacovigilance services play a pivotal role in safeguarding public health by monitoring and evaluating the adverse effects of drugs once they are on the market. This process helps detect unknown side effects and enhances the safe use of pharmaceutical products.

What Are Pharmacovigilance Services?

Pharmacovigilance (PV) refers to the science of detecting, assessing, understanding, and preventing adverse effects or any other drug-related problems. Pharmacovigilance services are essential in collecting data from healthcare providers, patients, and pharmaceutical companies to assess the risk-benefit profile of medicinal products. This system ensures that all stakeholders are alerted about the potential risks associated with drug usage while emphasizing patient safety.

The process of pharmacovigilance goes beyond mere monitoring. It includes robust data management, analysis, and interpretation, which ultimately aids in improving drug formulations and adjusting medical guidelines. For pharmaceutical companies, these services are fundamental in maintaining compliance with regulatory authorities like the FDA or EMA.

The Importance of Pharmacovigilance in Drug Safety

The pharmaceutical industry faces enormous pressure to ensure that medicines are safe for public use. Drug development undergoes extensive clinical trials before being approved for public use, but real-world application often reveals unknown side effects or complications. Pharmacovigilance services offer a continuous evaluation mechanism that enables the identification of potential hazards at a larger scale and ensures that drug safety is continuously monitored post-launch.

For example, reports from patients using the medication or healthcare professionals administering them can highlight side effects not observed during clinical trials. These reports are systematically collected, analyzed, and communicated to the necessary regulatory bodies and manufacturers, triggering label changes, warnings, or even product recalls.

Key Elements of Effective Pharmacovigilance

Pharmacovigilance services focus on several key areas, ensuring that drugs used by the general population remain safe and effective. Some critical elements include:

Signal Detection and Risk Management

Signal detection refers to identifying new or unexpected adverse reactions related to a drug. It is an essential element of pharmacovigilance services as it allows for early identification of risks. When a signal is detected, further investigation and studies are conducted to confirm if the risk is linked to the drug, enabling regulatory authorities to take necessary actions.

Risk management, on the other hand, involves creating strategies to minimize the identified risks. Companies employ risk minimization measures such as additional clinical trials or altering drug labeling to inform healthcare professionals and patients about potential risks.

Pharmacovigilance Consulting Services

Pharmaceutical companies often collaborate with pharmacovigilance consulting services to navigate the complexities of global drug safety regulations. These consultants provide expertise in evaluating safety data, reporting to regulatory authorities, and implementing safety surveillance programs.

Pharmacovigilance consultants also guide pharmaceutical companies in setting up comprehensive safety databases, signal detection programs, and risk management plans, ensuring their processes align with global regulatory requirements.

Role of Pharmacovigilance in Drug Efficacy

While pharmacovigilance is primarily focused on safety, it also plays a significant role in ensuring that drugs maintain their efficacy over time. By tracking real-world usage, pharmacovigilance services help determine if a drug’s benefits continue to outweigh its risks in broader patient populations or long-term use scenarios.

For example, data collected through integrated surveillance can show whether a drug’s efficacy decreases in specific demographic groups or interacts poorly with other medications. This ongoing analysis is essential in refining dosage recommendations and optimizing therapeutic effects.

Support from Integrated Site Management

Effective pharmacovigilance is also closely tied to integrated site management, which involves coordinating data collection and analysis across multiple healthcare sites. Integrated site management ensures consistent data reporting, fostering a cohesive understanding of drug safety and efficacy across regions and demographics.

How Pharmacovigilance Consultants Add Value

Pharmaceutical companies often face challenges in managing the vast amounts of data generated by global drug use. Pharmacovigilance consultants are vital in this regard, providing companies with expert guidance on handling adverse event reports, regulatory compliance, and managing drug safety systems. They help in creating strategies that not only mitigate risks but also optimize drug use in diverse populations.

The Future of Pharmacovigilance Services

With technological advancements, pharmacovigilance is poised to become even more efficient and effective. Automation, artificial intelligence, and big data are being integrated into the PV process to enable real-time adverse event reporting and signal detection. The future promises to enhance predictive modeling, allowing pharmaceutical companies to anticipate drug-related risks even before they manifest in the population.

Regulatory Evolution and Global Collaboration

Global collaboration between regulatory bodies and pharmaceutical companies will strengthen the pharmacovigilance framework. As the regulatory environment becomes more stringent, the demand for comprehensive pharmacovigilance services will grow, ensuring that every drug on the market meets the highest safety standards.

Pharmacovigilance services will continue to be instrumental in keeping the healthcare system safe and effective for all. With pharmacovigilance consulting services, companies can manage complex safety requirements efficiently, ensuring they adhere to global regulations and safeguard public health.

Conclusion

In the evolving landscape of healthcare, pharmacovigilance services are indispensable in maintaining drug safety and efficacy. By actively monitoring adverse events and employing risk management strategies, these services provide an ongoing evaluation of medicines, ensuring they remain safe for public use.

Whether through pharmacovigilance consulting services or comprehensive data collection via integrated site management, pharmacovigilance’s role in the pharmaceutical industry and public health is undeniable. As technology advances, these services’ effectiveness will only grow, enhancing the safety and efficacy of medications for future generations.

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