Does Spravato Cause Weight Gain?

Spravato, a nasal spray form of esketamine, is a newer treatment option for individuals with treatment-resistant depression (TRD) who have not responded to other medications. As with many medications, people have questions about its potential side effects, including the possibility of weight gain. So, does Spravato cause weight gain? In this article, we’ll explore how Spravato works, its benefits, and whether weight gain is something to worry about.

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“Curious if Spravato causes weight gain? Learn about Spravato’s effects, benefits, and if weight changes are a concern in treatment-resistant depression care.”

What is Spravato?

Spravato is a nasal spray containing esketamine, a form of ketamine. Approved by the FDA, it is specifically used for individuals who suffer from treatment-resistant depression—a type of depression that has not improved with at least two other antidepressant medications. Spravato is typically administered under the supervision of a healthcare provider and is used in conjunction with an oral antidepressant.

How Does Spravato Work?

Unlike traditional antidepressants, which primarily target serotonin, dopamine, or norepinephrine levels, Spravato targets the brain’s glutamate system. Glutamate is a neurotransmitter associated with learning and memory, and it plays a role in mood regulation. By influencing glutamate, Spravato can have a rapid antidepressant effect, often working in hours or days, which is significantly faster than most traditional antidepressants.

Common Side Effects of Spravato

As with any medication, Spravato can have side effects. Some of the most commonly reported side effects include:

• Dizziness
• Nausea
• Increased blood pressure
• Dissociation (feeling disconnected from reality)
• Sedation or drowsiness

These side effects typically occur within the first two hours of dosing and gradually lessen with time.

Can Spravato Cause Weight Gain?

Weight gain is a concern for many people who start new medications, especially for mental health. So, does Spravato lead to weight gain? Currently, weight gain is not listed as a common side effect of Spravato. In clinical studies, weight gain has not shown up as a significant concern compared to other antidepressants that can potentially impact body weight.

Why Do Some Medications Cause Weight Gain?

Understanding why medications can cause weight gain can help clarify why Spravato might be different. Many antidepressants can increase weight by:

• Altering metabolism: Some medications slow down the body’s metabolism.
• Increasing appetite: Certain drugs stimulate the appetite center in the brain.
• Causing fluid retention: Some medications can make the body retain water.

Since Spravato affects glutamate rather than serotonin or other neurotransmitters tied to appetite and metabolism, it is less likely to impact weight.

Is Weight Gain Common with Spravato?

No, weight gain is not commonly associated with Spravato. Although individual reactions vary, weight changes are typically minimal with this treatment. Clinical trials and patient reports do not show a high rate of weight gain among Spravato users.

Managing Weight While on Spravato

While Spravato itself may not cause significant weight changes, you may still want to monitor your weight for overall wellness. Here are a few healthy habits to help manage weight:

1. Regular Exercise: Engage in both aerobic exercises and strength training.
2. Balanced Diet: Focus on whole foods, lean proteins, and fiber-rich vegetables.
3. Stay Hydrated: Drinking enough water can prevent overeating and manage cravings.
4. Regular Monitoring: Keep track of your weight and any dietary changes.

If you’re concerned about weight changes, consult your healthcare provider for personalized guidance.

Other Considerations for Spravato Users

Spravato is known for its quick onset, making it suitable for individuals needing fast relief from severe symptoms. However, it also requires close medical supervision due to potential side effects like blood pressure spikes and dissociation. Always discuss any concerns with your doctor to ensure the treatment aligns with your health needs.

Who Should Consider Spravato?

Spravato is usually considered when other antidepressants have not been effective. It’s recommended for people:

• With treatment-resistant depression
• Who haven’t responded to at least two other antidepressants
• Needing rapid relief due to severe depression

Alternatives to Spravato

If you’re uncertain about Spravato, there are other treatments available for treatment-resistant depression, including:

• Electroconvulsive therapy (ECT): Uses electrical currents to influence brain activity.
• Transcranial magnetic stimulation (TMS): Non-invasive magnetic pulses target mood-regulating brain areas.
• Psychotherapy: Particularly cognitive-behavioral therapy (CBT), which addresses negative thought patterns.

Each option has its own pros and cons, so it’s essential to discuss alternatives with a mental health professional.

Conclusion

In conclusion, Spravato does not typically cause weight gain, and it is not listed as a common side effect. While some individuals may have unique responses, weight changes are generally minimal. If you’re considering Spravato, remember that it’s one of the few treatments that can offer quick relief for treatment-resistant depression. Always consult with your healthcare provider to make the best decision based on your specific health needs.

Frequently Asked Questions (FAQs)

1. Can Spravato cause weight gain?
No, weight gain is not a common side effect of Spravato, according to clinical studies and patient experiences.

2. How fast does Spravato work?
Spravato often works within hours to days, providing rapid relief for individuals with treatment-resistant depression.

3. Are there any dietary restrictions with Spravato?
There are no specific dietary restrictions, but maintaining a healthy diet can support overall well-being while on any medication.

4. Can Spravato cause other long-term side effects?
Some users may experience side effects like dissociation or blood pressure changes, but these are usually short-lived and managed by healthcare providers.

5. Is Spravato safe for everyone with depression?
Spravato is typically recommended for those with treatment-resistant depression and is not the first-line treatment. Always consult with a doctor to determine if it’s appropriate for your situation.