Does Spravato Cause Weight Gain? Understand the Side Effects

Spravato, an innovative treatment for depression, has offered hope for those who haven’t found relief from traditional antidepressants. However, as with any medication, people may be concerned about possible side effects, including weight gain. In this article, we’ll explore whether Spravato causes weight gain, how it works, and what to expect when taking it. Understanding the potential effects of this treatment can help you make informed decisions with your health care provider.

What is Spravato, and How Does it Work?

Spravato (esketamine) is a nasal spray approved by the FDA in 2019 specifically for treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal thoughts. Unlike traditional antidepressants, which target neurotransmitters like serotonin, Spravato acts on glutamate, a different neurotransmitter involved in mood regulation.

“Spravato provides a rapid-acting antidepressant effect, often within hours, which is a breakthrough for many with severe depression,” explains Dr. Emily Rivers, a psychiatrist specializing in treatment-resistant depression.

Spravato is administered under medical supervision, typically in a healthcare setting, due to the risk of dissociative side effects and the potential for misuse. It’s used alongside an oral antidepressant, with patients undergoing regular monitoring.

Does Spravato Cause Weight Gain?

For those concerned about weight gain—a common side effect of many antidepressants—the good news is that current research indicates Spravato does not typically lead to weight gain. Unlike SSRIs (selective serotonin reuptake inhibitors) and other antidepressant classes often associated with weight changes, Spravato’s mechanism of action through glutamate appears to have little impact on weight.

In clinical trials, weight gain was not observed as a common side effect. Most patients did not report significant weight changes during the duration of their treatment. However, it’s essential to keep in mind that responses to medications vary, and some people may experience weight fluctuations due to individual factors, which we’ll discuss further below.

Common Side Effects of Spravato

While weight gain is not a typical side effect, Spravato does have some other common side effects to be aware of:

1. Dissociation: Some patients may feel detached from reality, experience visual distortions, or feel disconnected from their bodies. This is usually temporary and monitored by healthcare providers.
2. Sedation: Drowsiness is common after taking Spravato. Patients are advised not to drive or operate heavy machinery for at least 24 hours post-treatment.
3. Increased Blood Pressure: Spravato can cause a temporary increase in blood pressure, which is why it’s administered in a clinical setting.
4. Nausea and Vomiting: Some patients report feeling nauseous, which may lessen over time as the body adjusts to the medication.

“Spravato’s side effects are unique due to its method of delivery and its rapid-acting effects. This is why it’s so closely monitored in clinical settings,” notes Dr. John Marcus, a clinical pharmacologist.

Each of these side effects is manageable under the supervision of healthcare professionals, which is why Spravato is given only in controlled environments.

Why Antidepressants Often Lead to Weight Gain

Weight gain is a known side effect of many antidepressants, especially SSRIs and tricyclics. These medications affect neurotransmitters that can influence metabolism, appetite, and hormone levels. Some patients also experience weight gain due to improved appetite once their depression symptoms lessen.

“Many antidepressants lead to changes in appetite, metabolism, or energy levels, which can result in weight gain,” says Dr. Lisa Graham, a mental health specialist. “However, Spravato’s unique mechanism does not generally produce these effects.”

Since Spravato works differently, it typically doesn’t trigger these same metabolic or appetite-related changes, making weight gain far less likely.

Factors That May Affect Weight While on Spravato

Even though Spravato itself may not directly cause weight gain, certain individual factors can influence weight changes while on this medication:

1. Lifestyle Habits: Diet, exercise, and sleep play a crucial role in weight management. Patients may need to pay extra attention to these factors, especially during intense treatment periods.
2. Concurrent Medications: Spravato is usually prescribed alongside an oral antidepressant. Some antidepressants are more likely to cause weight gain, so if you’re taking one with known weight-related side effects, it may affect your overall experience.
3. Mental Health Status: Improvements in mental health can sometimes impact appetite and energy. For example, some people may feel an increased appetite when they start to feel better, while others may notice a decrease in appetite.
4. Stress Levels: Stress can influence weight gain or loss. If Spravato is relieving symptoms of depression, you may also notice changes in stress-related behaviors that previously affected weight.

Understanding these individual factors can be helpful in assessing any weight changes during treatment.

How to Manage Weight While Taking Spravato

If you’re concerned about weight changes, here are some strategies to help you manage your weight effectively:

1. Maintain a Balanced Diet: Eating a diet rich in whole foods, including lean proteins, whole grains, and plenty of fruits and vegetables, can help manage weight effectively.
2. Stay Physically Active: Regular exercise supports weight management and overall mental health. Aerobic exercise, strength training, and yoga are excellent for both physical and mental well-being.
3. Monitor Progress with Your Healthcare Team: Regular check-ins with your healthcare provider allow you to address any concerns you may have, including any unexpected weight changes.
4. Manage Stress Through Mindfulness or Therapy: Stress can impact weight, so practices like meditation, breathing exercises, or cognitive behavioral therapy (CBT) can help.

“Adopting a balanced lifestyle can make all the difference in managing any potential weight-related concerns,” recommends Dr. Rachel Torres, a wellness consultant.

Implementing these habits can help you feel your best during your treatment journey.

Final Thoughts: Understanding Spravato’s Role in Your Treatment

For those with treatment-resistant depression or major depressive disorder, Spravato offers a powerful new approach to relief. Weight gain, a concern with many traditional antidepressants, is rarely associated with Spravato, thanks to its unique mechanism of action through the glutamate system.

However, managing overall health, including weight, requires a holistic approach. A balanced diet, regular exercise, and stress management techniques can all support your well-being and help ensure your treatment journey is as smooth as possible.

“Spravato is a game-changer for those who haven’t found relief elsewhere,” says Dr. Sandra Evans, a psychologist. “But like any treatment, it’s essential to approach it with a full understanding of both its benefits and any potential side effects.”

Whether you’re considering Spravato or already using it, speak openly with your healthcare provider about any concerns, including weight. They can provide guidance specific to your needs and help you manage any side effects effectively. Taking an active role in your treatment allows you to benefit fully from Spravato’s potential to improve both mental and physical well-being.