As the biopharmaceutical industry explores innovative and novel ways to handle the complexities of drug formulation, artificial intelligence (AI) technology is experiencing a marked rise in incorporation. Processor-intensive tasks such as antibody engineering, which were once hindered by time and resource constraints, are now becoming quicker and more efficient thanks to AI. AI antibody engineering employs…
People who carry the ALDH2 gene mutation experience facial redness when drinking alcohol or alcoholic beverages. This is because the ALDH2 gene mutation leads to a significant reduction in the activity of acetaldehyde dehydrogenase 2, which leads to the accumulation of acetaldehyde, an intermediate metabolite of alcohol, which in turn leads to symptoms such as…
In the complex race of cancer treatment, the evolution of breast cancer therapy resembles a dynamic battle of “as high as the mountain, the magic rises higher.” Every technological breakthrough not only advances patient survival rates but also reveals deeper biological challenges. The history of breast cancer treatment is an ongoing process of combating…
In recent years, immune checkpoint inhibitors (ICIs) have emerged as a significant breakthrough in cancer therapy, reshaping traditional treatment paradigms. PD-1/PD-L1 pathway inhibitors have been widely used across various cancer treatments, demonstrating impressive efficacy. As PD-(L)1 inhibitor therapies continue to mature, pharmaceutical giants have turned their attention to PD-(L)1 bispecific antibodies (BsAbs), a new class of…
Next-generation sequencing (NGS) has become a pivotal technology in cancer diagnostics, offering exceptional sensitivity, throughput, and cost efficiency. By enabling comprehensive genomic analysis, NGS has transformed how cancer is understood and detected. Advanced platforms now integrate technologies such as Whole Exome Sequencing (WES) and Circle-Seq-based eccDNA identification, providing researchers with powerful tools to unravel the complexity…
The field of biopharmaceuticals is playing an increasingly pivotal role in medical treatment but is encountering several challenges. One pressing issue is the short half-life of many biopharmaceutical products, which leads to rapid degradation and clearance from the patient’s body, necessitating frequent dosing. In this article, we explore how half-life extension strategies in drug development…
Breast cancer, a widely recognized term, stands as one of the most prevalent malignant tumors among women. Nevertheless, the medical community remains captivated by the elusive origins of breast cancer. In recent years, scientists have shifted their focus towards the microscopic world within cells, particularly honing in on the protein synthesis factories within cells –…
The term “single cell” refers to an individual cell, isolated and examined on its own. Analysis conducted specifically on individual cells is collectively referred to as single-cell sequencing analysis, while sequencing performed on these isolated cells is termed single-cell sequencing. Sequencing multiple cells or a group of cells falls outside the realm of single-cell sequencing. For instance,…
Non-alcoholic fatty liver disease (NAFLD), as its name indicated, is a condition caused by abnormal or excessive fat buildup in liver, which is not a result of heavy alcohol use. It has become a common chronic liver disease and is affecting up to 25% of people worldwide. Most people have no symptoms, and 2% to 5% of people will…
Therapeutic antibodies, engineered through biotechnology, represent a specialized class of antibodies used in disease treatment. These antibodies are designed to target specific disease markers, such as malignant tumors, autoimmune disorders, and infectious diseases. Compared to traditional antibody therapies, therapeutic antibodies offer higher specificity and fewer side effects. In the realm of immunotherapy, antibody-dependent cell-mediated…
