catalinagarcia

Vascular endothelial growth factor receptor type2 (VEGFR2) is a receptor tyrosine kinase (RTK) overexpressed in a variety of cancer cells especially in metastatic cancer cells such as melanoma and renal cancer. It belongs to the VEGFR superfamily and plays important roles in tumor cell proliferation, survival, invasion and tumor angiogenesis owing to high dependency of tumor cells on the tumor vasculature. Learn more: anti-VEGFR2 CAR-T in vivo assay

A New Approach to mRNA Delivery

Lentivirus, adenovirus, adeno-associated virus (AAV), and lipid nanoparticle (LNP) are currently the main delivery vectors used for human gene therapy, but some of these delivery vectors can randomly integrate into the genome, some are ineffective, and some can trigger unintended immune responses. The entire biomedical community is striving to develop new and more powerful molecular therapies,…

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An AIDS drug may treat neurodegenerative disease

At first glance, there appears to be no connection between the AIDS drug CCR inhibitor Maraviroc and neurodegenerative diseases. Maraviroc, a CCR5 inhibitor already approved in 2007, mechanistically binds to the CCR5 molecule and blocks the association of the HIV protein gp120 with the CCR5 receptor, resulting in the inability of HIV to enter the body. In…

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