For cat lovers, the most tragic thing is probably the cat allergy. As soon as you get close to the cat, you sneeze, have a runny nose, or itchy eyes, skin rashes, and even asthma attacks. There are many people who are allergic to cats, with about 1 in 10 in the population. In some areas,…
Influenza A Virus (IAV) is one of the most important causes of respiratory infections and has caused tens of millions of deaths in several pandemic outbreaks throughout human history. In recent years, the recurrence of influenza epidemics in poultry and swine flocks has posed a serious threat to public health safety, thus, research on the…
Within the intricate microcosm of human cells, comparable to a sophisticated symphony orchestra, ribosomes assume the role of conductors, finely coordinating the synthesis of proteins—the fundamental building blocks of life. Yet, disturbances in ribosomal function intricately connect with cellular dysfunction, playing a significant role in the initiation and progression of diverse diseases. Cellular ribosomal anomalies…
The field of biopharmaceuticals is playing an increasingly pivotal role in medical treatment but is encountering several challenges. One pressing issue is the short half-life of many biopharmaceutical products, which leads to rapid degradation and clearance from the patient’s body, necessitating frequent dosing. In this article, we explore how half-life extension strategies in drug development…
Lentivirus, adenovirus, adeno-associated virus (AAV), and lipid nanoparticle (LNP)Â are currently the main delivery vectors used for human gene therapy, but some of these delivery vectors can randomly integrate into the genome, some are ineffective, and some can trigger unintended immune responses. The entire biomedical community is striving to develop new and more powerful molecular therapies,…
At first glance, there appears to be no connection between the AIDS drug CCR inhibitor Maraviroc and neurodegenerative diseases. Maraviroc, a CCR5 inhibitor already approved in 2007, mechanistically binds to the CCR5 molecule and blocks the association of the HIV protein gp120 with the CCR5 receptor, resulting in the inability of HIV to enter the body. In…
